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Human Metabolism Notes

Human Metabolism Notes

Vitamin Absorption



Minerals

You need a very little amount of minerals in your body (trace amount).

  • Too much minerals will become toxic for you.
    • For example, massive doses of zinc will kill you.
  • Iron
    • Primary source of iron is from meat (because meat has red blood cells which have heme groups on the hemoglobin)

 

    • Iron goes from lumen to epithelial cell by ferratin. Ferratin is in the epithelial cell that binds with iron so it won’t escape to the lumen. Only 10% of the iron goes from cell to the capillary. In the capillary, a protein called transferrin binds to iron. This protein takes it throughout the body, but more especially to the bone marrow to make hemoglobin.
    • The 90% of the iron bound to ferratin goes out to the lumen.
      • This means that the 90% of the iron goes to the fecal matter and eliminated.
    • The iron levels in the lumen dictate how much ferratin is made in the epithelial cell.

 

  • Calcium


  • Hormones that affect human metabolism

    • Thyroxine (thyroid hormone)
        • What is Hypothyroidism?


        • Growth Hormone
          • Comes from anterior pituitary gland
          • Bind to G protein of the target cell
          • Chondrocytes are sensitive to growth hormone
            • Too much GH can lead to gigantism (can be caused by tumor to pituitary gland, overproducing growth hormone).
            • Too much GH for adults can lead to acromegaly
            • Too little GH causes dwarfism
              • Dwarfism (the limbs don’t grow as long because GH doesn’t affect the epiphyseal plates of the lone bones

         

        • Cortisol
          • From adrenal cortex of adrenal gland
          • Released when stressed out
          • Sympathetic ns releases cortisol
          • Cortisol suppresses immune system
          • Increase break down of proteins (proteolysis) and lipids (lipolysis)

         

        Testosterone

        • Decrease adipose tissue ( by lipolysis)
        • Increase protein synthesis
          • Goes into the cell (like skeletal muscle cell) and diffuses into it and binds to a receptor protein. Then moves to nucleus of cell and binds to gene. Turning on the genes increases transcription which leads to translation and makes more protein

        Estrogen

        • Increases fat adipose tissue (increase fat deposition)
        • That’s why women are curvier

        Melatonin

        • Comes from pineal gland
          • Pineal gland releases melatonin and affects sleep/wake cycles (circadian rhythms)

        Temperature Regulation

        Controlling Hunger

         



        Physiology Notes
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